Safe and effective vaccines are urgently needed to respond to the SARS-CoV-2 pandemic. Controlled human infection studies have been suggested as a mechanism for expediting vaccine development, however significant ethical considerations continue to be debated. This article by Meagan E. Deming, M.D., Ph.D., Nelson L. Michael, M.D., Ph.D., Merlin Robb, M.D., Myron S. Cohen, M.D., and Kathleen M. Neuzil, M.D., M.P.H. focussed on the practicalities of human infection studies in vaccine development for SARS-CoV-2. 


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