NEW! Community Engagement with Vaccine Research

A new theme page is now live on Mesh exploring public and community engagement with vaccine studies. Developed following a workshop on the topic, the area shares videos, exercises, projects, links to published literature, and many free guidelines and tools. Read more


Perceptions about controlled human infection model (CHIM) studies among members of ethics committees of Indian medical institutions: A qualitative exploration

by Abhishek Sharma, Aditi Apte, Medha Rajappa, Manjulika Vaz, Vina Vaswani, Shifalika Goenka, Samir Malhotra, Rashmi Sangoram, Sabitha Lakshminarayanan, Suganya Jayaram, Jayanthi Mathaiyan, Knadeejath Farseena, Prarthna Mukerjee, Surinder Jaswal, Amol Dongre, Olinda Timms, Nusrat Shafiq, Rakesh Aggarwal, Manmeet Kaur, Sanjay Juvekar, Amrita Sekhar, Gagandeep Kang

Introduction: Controlled Human Infection Model (CHIM) studies provide a unique platform for studying the pathophysiology of infectious diseases and accelerated testing of vaccines and drugs in controlled settings. However, ethical ...

Practical considerations for a TB controlled human infection model; the case for TB-CHIM in Africa, a systematic review of the literature and report of 2 workshop discussions in UK and Malawi

by Stephen B. Gordon, Simon Sichone, Anthony E. Chirwa, Phoebe Hazenberg, Zacharia Kafuko, Daniela M. Ferreira, Joanne Flynn, Sarah Fortune, Shobana Balasingam, Giancarlo A. Biagini, Helen McShane, Henry Mwandumba, Kondwani Jambo, Keertan Dedha, Nimisha Raj Sharma, Brian D. Roberston, Naomi Walker, Ben Morton

Background: Tuberculosis (TB) remains a major challenge in many domains including diagnosis, pathogenesis, prevention, treatment, drug resistance and long-term protection of the public health by vaccination. A controlled human infection model ...