Welcome to this global knowledge hub and community of practice for Human Infection Studies. This open access space brings together knowledge, tools, and methods to support researchers across the world working in – or interested in working in – human infection studies. Across this hub you can find the latest research, share protocols and exchange knowledge with your peers in this field. Topics range from study set-up, ethical considerations, and regulation of challenge agents. If there's something you'd like to see please start a discussion or get in touch.
Watch the video below from the Wellcome Trust Vaccine Group to find out what are human infection studies and why they're important.
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In early 2020, the UK started exploring the feasibility of establishing a human challenge study with SARS-CoV-2. This publication describes the public consultation, the results of which were considered in the design and approval of the study. Read more
Virological & clinical results from the first SARS-CoV-2 human challenge study showed no serious safety signals & detailed characteristics of early infection & their public health implications Read more
Elaborating international consensus & guidance in biomedical research involving healthy volunteers, including vulnerable participants & human infection challenge studies Read more
Participants’ experiences of human infection studies in Malawi provide the basis of what can be acceptable for this research in lower-income countries & where study procedures could be adjusted Read more
This webinar from Sep 2020 discusses ethical &scientific principles for controlled human infection challenge studies, risk mitigation steps taken in previous such studies in malaria & how this might be applied in the context of COVID-19 vaccine development Read more
This cross-sectional study showed competence was lowest for Controlled Human Infection Model designs & recommends prioritising relevant training of ethics committee members Read more
This study suggests that the general Indian public involved had strong views of safety, expectation of safeguards & ideas of how such research can be regulated. Read more
A new theme page is now live on Mesh exploring public and community engagement with vaccine studies. Developed following a workshop on the topic, the area shares videos, exercises, projects, links to published literature, and many free guidelines and tools. Read more
Human infection (or challenge) studies involve the intentional administration of a pathogen (challenge agent) to volunteers. The selection, isolation, development and production of the challenge agent is one of the ...
Viewpoint of a WHO Advisory Group Tasked to Consider Establishing a Closely-monitored Challenge Model of Coronavirus Disease 2019 (COVID-19) in Healthy Volunteers
Georgetown University's School of Nursing & Health Studies recently published an article titled "Answering Common Questions About Herd Immunity and Vaccination". This article discusses the science behind herd immunity ...
We have provided a non-exhaustive list of guidelines, tools, templates and documents - as well as links to external resources - that are relevant to the development of health research, trials studies in general, and data management and sharing. Please check out our dedicated pages for Resources on Trials, Health Research, and Data Management and Sharing
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There are many considerations for conducting ethical and safe human infection studies. The human infection studies knowledge hub invites your contributions to several theme areas that will be developed over the coming months with a focus on Ethical considerations, Regulation, and Public & Community engagement.
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